Run introduces us to Diane Sherman (Paulson) shortly after she was born. Doctors are working hard to save the life of their incredibly little baby. Seventeen years later we are introduced to Chloe (Allen), who lives with a variety of medical conditions – including irregular heartbeat, diabetes, asthma, and paraplegia – but is ready to begin her independent college life away from her mother. In public, Diane seems upset when her daughter goes to college after a life at home, but when they are alone she overly controls and treats Chloe like a child.